Description
Cleveland Clinic International Perspectives on Liver Failure in Critical Care 2025
A targeted, one-day virtual symposium built around ICU decision-making in Acute Liver Failure (ALF) and Acute-on-Chronic Liver Failure (ACLF)—bridging advanced medical management, neuromonitoring, renal support, and high-stakes transplant triage.
ALF + ACLF ICU Strategies
Neuromonitoring
Hemodynamics
HRS-AKI + CRRT
Transplant Candidacy
MILU Protocols
Neuromonitoring
Hemodynamics
HRS-AKI + CRRT
Transplant Candidacy
MILU Protocols
Date: Tuesday, October 7, 2025 • Format: Virtual / Live Stream • Delivery via Google Drive (unlimited access + downloadable files).
Program Overview
International Perspectives on Liver Failure in Critical Care 2025 is a focused symposium designed for clinicians caring for critically ill liver patients.
Built on the workflow of Cleveland Clinic’s Medical Intensive Liver Unit (MILU), the course emphasizes multidisciplinary ICU protocols for high-risk ALF/ACLF patients—covering hemodynamic stabilization, neurologic risk management, renal-hepatic crosstalk, and transplant decision-making when time and physiology are both limited.
Built on the workflow of Cleveland Clinic’s Medical Intensive Liver Unit (MILU), the course emphasizes multidisciplinary ICU protocols for high-risk ALF/ACLF patients—covering hemodynamic stabilization, neurologic risk management, renal-hepatic crosstalk, and transplant decision-making when time and physiology are both limited.
Why This Course Matters
- Niche ICU focus: Liver failure in critical care is underrepresented in broader hepatology meetings—this course addresses the ICU “gray zones” directly.
- MILU playbook: Learn how a dedicated liver ICU approaches high-MELD physiology, shock, encephalopathy, and multi-organ failure.
- Transplant triage realism: Covers the hardest calls—when high-risk transplant is the only viable option versus when a patient is “too sick for transplant.”
Who Should Enroll
- Intensivists (Critical Care Physicians) managing ALF/ACLF and decompensated cirrhosis in the ICU
- Hepatologists & Gastroenterologists seeking deeper critical care updates for liver failure patients
- Anesthesiologists involved in liver transplantation and peri-operative risk management
- Advanced Practice Providers (NPs/PAs) working in MICU or liver transplant units
What You Will Learn
Hemodynamic Stabilization
Managing vasodilation, shock physiology, and cirrhotic cardiomyopathy patterns seen in liver failure ICU care.
Neuromonitoring: “When and How”
Practical approaches to cerebral edema and intracranial hypertension risk in high-grade hepatic encephalopathy.
Renal–Hepatic Crosstalk
Updates on HRS-AKI and timing decisions for CRRT as a bridge to transplant or recovery.
Transplant Candidacy & “Too Sick” Decisions
How teams weigh physiologic reserve, multi-organ failure, and ethical considerations when transplant is the only option.
ACLF Prioritization
Strategies to optimize waitlist outcomes and reduce mortality in high-risk ACLF patients.
Multidisciplinary ICU Protocol
Coordination between intensivists, hepatologists, and transplant teams to align care with time-critical decisions.
Agenda (Tuesday, October 7, 2025)
| Time | Session | Faculty |
|---|---|---|
| 12:05 pm | Evolution of Liver Critical Care – Lessons Learned | Georg Auzinger, Dr Med Univ, FRCP, AFICM, EDIC |
| 12:30 pm | Management of ALF – Multidisciplinary Approach | Constantine (Dean) Karvellas, MD, SM, FRCPC, FCCM |
| 12:55 pm | Neuromonitoring – When and How | Catherine Hassett, DO |
| 1:20 pm | Hemodynamic Alterations and Management Strategies | Aanchal Kapoor, MD, MEd |
| 1:45 pm | Panel Discussion and Q&A | Moderators: Aanchal Kapoor, MD, MEd; Eduardo Mireles-Cabodevila, MD • Faculty: Auzinger; Karvellas; Hassett |
| 2:00 pm | Break | — |
| 2:15 pm | Peri-op Cardiac Risk Assessment & Approach to Transplant in ALF/ACLF | Maan Fares, MD |
| 2:40 pm | AKI / Hepatorenal Syndrome and Bridge to Transplantation | Andrew Allegretti, MD, MSc |
| 3:05 pm | ACLF and Transplant Waitlist Mortality Prioritization | Jody C. Olson, MD, FACP, FCCM |
| 3:30 pm | When It Is Too Sick for Transplant | Christina Lindenmeyer, MD |
| 3:55 pm | Peri-op Hemodynamic Management | Matt Siuba, DO |
| 4:20 pm | Panel Discussion and Q&A | Moderators: Jacek B. Cywinski, MD, FASA; Siddharth Dugar, MD; Koji Hashimoto, MD, PhD • Faculty: Fares; Allegretti; Olson; Lindenmeyer; Siuba |
| 4:35 pm | Wrap Up | Aanchal Kapoor, MD, MEd; Christina Lindenmeyer, MD; Eduardo Mireles-Cabodevila, MD |
| 4:40 pm | Adjourn | — |
Access & Delivery
All materials are delivered via Google Drive with unlimited access and downloadable files for offline study.
Medicine.ac does not provide CME, CE, or credits of any kind.
Bundle & Save
Save 15% on Bundles
Get 15% off when purchasing two or more courses together. This bundle discount is permanent and unlimited.
Frequently Asked Questions
Is this course only for transplant centers?
No. The content is designed for any ICU team managing liver failure. It is especially valuable for pre-transplant and high-acuity liver patients, but the ICU physiology and decision-making applies broadly.
Does it cover ALF and ACLF separately?
Yes. Sessions address ALF management and the unique complexities of ACLF, including transplant prioritization and ICU risk assessment.
Will neuromonitoring and cerebral edema risk be discussed?
Yes. The agenda includes a dedicated neuromonitoring session focused on “when and how” to monitor for cerebral edema and intracranial hypertension in severe hepatic encephalopathy.
How is access delivered?
All materials are delivered via Google Drive with unlimited access and downloadable files for offline study.
Are credits included?
No. Medicine.ac does not provide CME, CE, or credits of any kind.
Student & Physician Experiences
★★★★★
ICU Attending (D.R.)
“This was the most practical liver-failure ICU content I’ve seen—especially the hemodynamics and the ‘too sick for transplant’ framework. Immediately applicable.”
★★★★★
Hepatology Fellow (L.M.)
“Excellent bridge between hepatology and critical care. The neuromonitoring talk and CRRT timing discussion helped clarify real ICU thresholds.”
★★★★☆
Transplant Anesthesia (K.S.)
“Strong peri-op risk and hemodynamic management content. The panels addressed the real-world dilemmas we face with ALF/ACLF candidates.”
